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Vagus Nerve Stimulation for Myelopathy

Vagus Nerve Stimulation for Myelopathy

Recruiting
18 years and older
All
Phase N/A

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Overview

The objective of this study is to generate preliminary data to establish the feasibility and effectiveness of transauricular vagus nerve stimulation (taVNS) to improve post-operative outcomes of moderate to severe degenerative cervical myelopathy (DCM)

Eligibility

Inclusion Criteria:

  • 18 years of age or older
  • Moderate or severe degenerative cervical myelopathy according to the mJOA
  • Decompression surgery planned

Exclusion Criteria:

  • • Pregnancy
    • Electrically active implants (e.g. pacemaker)
    • Known diagnosis of amyotrophic lateral sclerosis, multiple sclerosis, rheumatoid arthritis, concomitant thoracic and/or lumbar stenosis, spine tumor, HIV-related myelopathy
    • Ongoing cancer therapy
    • Ongoing use of immunomodulating or suppressive medication
    • Sustained bradycardia with a heartrate \<50 beats per minute for \> 5 minutes following admission.
    • Prior cervical spine surgery

Study details
    Degenerative Cervical Myelopathy

NCT07660250

Washington University School of Medicine

27 June 2026

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