Overview
The goal of this study is to establish the feasibility, tolerability, and preliminary efficacy of sleep-state transcranial magnetic stimulation (TMS) for enhancing plasticity in depression treatment.
Description
Healthy control participant cohort funded through K99MH141192 and depressed patient cohort funded through K99MH141192 and UM1TR004921.
Eligibility
Inclusion Criteria:
- Adults ages 18-65 years
- Current Major Depressive Disorder (MDD) diagnosis
- Failed ≥1 antidepressant medication
- Moderate-to-severe depression
- Stable antidepressant medication dose for ≥ 6 weeks prior to enrollment
- Healthy control participants are adults ages 18-65 years without current MDD symptoms, not taking antidepressant or antipsychotic medications, and without major psychiatric, neurological, substance use, medical conditions affecting brain function, or TMS/MRI contraindications.
Exclusion Criteria:
- Intellectual disability
- Significant head injury/neurological disorder
- Pregnancy or postpartum
- TMS/MRI contraindications
- Active substance use/suicidal ideation
