Overview
The purpose of this research is to evaluate the diagnostic role and clinical efficacy of investigational FET-PET/MRI in detecting MRI-occult primary or residual/recurrent functional pituitary adenomas (PAs) and its influence on clinical and surgical decisions.
Eligibility
Inclusion Criteria:
- Patients 18 to 75 years of age with biochemically proven CD, Acromegaly, or tumor hyperprolactinemia as per current Endocrinology guidelines.
- Clinical DCE-MRI protocol that is negative or equivocal for identifiable tumor.
- Patient willing to have surgery if lesion found, or already scheduled for surgery and lesion identification would be helpful.
- Able to provide informed consent and be capable of completing the imaging protocols.
- Female subjects of childbearing potential (women of childbearing potential \[WOCBP\]) must have a negative urine pregnancy test ≤48 hours prior to the 18F-FET injection.
Exclusion Criteria:
- Patients with contraindications to MRI or PET scans.
- Patients with known allergies to contrast agents or other imaging-related materials.
- Patients with severe medical conditions that preclude participation in the study (e.g. inability to lie supine for 30-60 minutes).
- Patients with successful MRI localization of the adenoma.
