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Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

Direct vs Standard SLT for Glaucoma: A Noninferiority Trial

Recruiting
18 years and older
All
Phase N/A
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Overview

This study compares two FDA-approved laser treatments for glaucoma: Direct Selective Laser Trabeculoplasty (DSLT) and Selective Laser Trabeculoplasty (SLT). Both procedures aim to lower eye pressure and prevent vision loss. DSLT is a newer, non-contact technique that may improve comfort and efficiency. Participants will be randomly assigned to receive either DSLT or SLT and followed for 12 months to assess eye pressure, safety, and treatment outcomes.

Eligibility

Inclusion Criteria:

  • Age ≥18 years
  • Diagnosis of OAG (including exfoliative or pigmentary) or OHT
  • Gonioscopically open angle (visible scleral spur 360°)
  • Ability to consent and comply with follow-up

Exclusion Criteria:

  • Angle-closure or secondary glaucomas
  • IOP \>35 mmHg despite therapy
  • Corneal pathology interfering with laser or IOP measurement
  • Recent ocular surgery (\<6 months)
  • Contraindications to study medications or procedures
  • Cognitive impairment preventing consent

Study details
    Open-angle Glaucoma (OAG)
    Ocular Hypertension (OHT)

NCT07408154

Medical University of South Carolina

13 May 2026

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FAQs

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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