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Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies

Early Pelvic Floor Physical Therapy for Women Undergoing Pelvic Radiation for Gynecologic Malignancies

Recruiting
18 years and older
Female
Phase N/A

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Overview

This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy.

Description

This is a single arm phase II study in which 28 patients who will be undergoing definitive pelvic external beam radiation therapy for cervical cancer will receive pelvic floor physical therapy 4 weeks after completing radiation therapy. The objective is to determine the rate of fecal incontinence at 3 months after RT in women undergoing pelvic radiation for gynecologic malignancies. The primary endpoint of this study is the rate of fecal incontinence at 3 months after RT utilizing the EORTC-QLQ CX24 validated survey. A score of 1 or higher will be classified as having incontinence.

Eligibility

Inclusion Criteria:

  1. Participants must be female.
  2. Patients must be 18 years old or older.
  3. Any patient with invasive cervical cancer who is planned for definitive chemoradiation.
  4. Plan to receive a minimum dose of 45Gy to pelvis per investigator.
  5. Willing to undergo pelvic floor physical therapy.

Exclusion Criteria:

  1. Any previous therapeutic pelvic radiation.
  2. Non-English speaking.

Study details
    Cervical Cancer
    Radiation Therapy Complication
    Pelvic Floor Disorders

NCT07447895

University of Cincinnati

13 May 2026

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