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A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

Recruiting
18-65 years
All
Phase 3
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Overview

The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.

Eligibility

Inclusion Criteria:

  • Body Mass Index ≥ 25 and \< 40 kg/m\^2
  • No serious medical problems or chronic diseases, specifically no type I or type II diabetes

Exclusion Criteria:

  • Another disorder that contributes to gastrointestinal symptoms
  • History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
  • History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
  • Exposure to any investigational medication within the past 60 days

Study details
    Nausea and Vomiting
    Obesity

NCT07446439

Vanda Pharmaceuticals

13 May 2026

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