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Physiological Study of High PEEP in Noninvasive Ventilation

Physiological Study of High PEEP in Noninvasive Ventilation

Recruiting
18 years and older
All
Phase N/A
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Overview

To investigate the physiological effects of high positive end-expiratory pressure (PEEP) during noninvasive ventilation in patients with hypoxemic respiratory failure, and to elucidate the mechanisms underlying high PEEP-induced improvement in oxygenation.

Eligibility

Inclusion Criteria:

  1. Age ≥ 18 years
  2. PaCO₂ ≤ 50 mmHg
  3. PaO₂/FiO₂ ≤ 300 mmHg
  4. Use of a noninvasive ventilator with esophageal pressure monitoring capability (e.g., Mindray SV70) -

Exclusion Criteria:

  1. Respiratory failure caused by heart failure, asthma, or acute exacerbation of chronic obstructive pulmonary disease (COPD) (COPD as a comorbidity may be included)
  2. Pneumothorax
  3. Patients who refuse to participate in this trial -

Study details
    Respiratory Failure With Hypoxia

NCT07503509

Chongqing Medical University

13 May 2026

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