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Assessing MB-Spirit for Psychological Well-being

Assessing MB-Spirit for Psychological Well-being

Recruiting
18-50 years
All
Phase N/A

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Overview

The field of surgery continues to benefit from innovative solutions, changing surgical methods and techniques. Evaluation in terms of efficacy and Quality-Safety is an essential topic that directly affects the introduction of innovations. It is essential to carry out a robust evaluation strategy for surgical innovations, even if these are often opposed to drug innovations. The aim of this study is to investigate the anthropological, socio-cultural and psychological differences of surgeons that influence the evaluation of surgical innovations.

Description

Forty-four individuals with high stress will be randomized 1:1, stratified by sex, to either MB-SPIRIT or wait-list. Participants will receive daily email with a link to a REDCap database to record minutes of formal meditation practice. Pre and post testing will occur within a 21-day testing period before or after the intervention. We will assess changes in spiritual well-being (Primary outcome), mindfulness, and use of character/virtue strengths (secondary outcomes). Changes in clinical symptoms will be explored. Participants will also complete a structured interview to assess developmental stage at the baseline time-point. Participants randomized to MB-Spirit will also undergo functional magnetic resonance imaging (fMRI) scanning before and after their program. Scans consist of a high-resolution gray matter scan, a 10-minute resting state scan and three 10-minute guided meditation scans. Participants will rate the 'depth' of each spiritual state they experience while they are in the scanner on a 5-point scale. As a manipulation check, after exiting the scanner they will be asked to describe the non-dual states and which virtues arose. We will also assess the acceptability of the task.

Eligibility

Inclusion Criteria:

  • Understands English
  • Able to attend all 8 classes
  • Able to travel to Boston for MRI scans

Exclusion Criteria:

  • claustrophobia, pregnancy, head trauma, metallic implants or devices contraindicating MRI, left-handed, conditions that alter cerebral blood flow or metabolism (e.g. stroke), current use of psychotropic medications, lifetime history of suicidality, homicidally, self-destructive acts, schizophrenia or psychosis.

Study details
    Stress

NCT07325448

Sara W Lazar

13 May 2026

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