Overview

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

Eligibility

Inclusion Criteria:

• Aged 60-75 years or older
• No regular resistance training habit (defined as ≥2 sessions per week) in the past year
• No musculoskeletal injuries within the past six months

Exclusion Criteria:

• Obesity (BMI \> 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
• Regular use of anti-inflammatory medications (e.g., NSAIDs).
• Smoking or alcohol abuse
• Inability to safely perform the prescribed resistance exercise movements
• Unable to fully comprehend the study information and instructions.