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Ventilation and Perfusion in Asthmatics

Ventilation and Perfusion in Asthmatics

Recruiting
18-75 years
All
Phase 4
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  • Simplified (AI rewritten)

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Overview

Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).

Eligibility

Inclusion Criteria:

  • Physician diagnosis of asthma
  • Baseline Forced Expiratory Volume in 1 Second (FEV1) \< 80% of predicted, with reversibility (10%) on post-bronchodilator spirometry
  • Adults, 18-75 years of age
  • Long-term inhaled controller medication consisting of or including an Inhaled corticosteroids (ICS) at a steady dose for at least 3 months before enrollment

Exclusion Criteria:

  • Current cigarette smoking or a past history of \>10 pack-year smoking
  • Current nicotine vaping
  • Pregnant and breast-feeding women
  • Respiratory infection within 4 weeks of proposed study date
  • Forced Expiratory Volume in 1 Second (FEV1) \< 50%
  • Inhaled corticosteroids (ICS)/fast-acting beta agonist (FABA) intolerance
  • Use of beta-blockers
  • Use of systemic glucocorticosteroids or oral methyl-xanthines within 30 days of planned study visit.

Study details
    Asthma

NCT07426458

University of Miami

13 May 2026

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