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Gas6 and Soluble MerTK in Periodontal Diseases

Gas6 and Soluble MerTK in Periodontal Diseases

Recruiting
18 years and older
All
Phase N/A
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Overview

This study aimed to investigate gingival crevicular fluid (GCF) and serum soluble MerTK (sMerTK) and Gas6 levels in periodontal health and disease. A total of 90 individuals, 30 patients with stage III grade B periodontitis, 30 with gingivitis and 30 periodontally healthy individuals were included. Whole-mouth and site-specific clinical periodontal parameters including probing depth, clinical attachment level, bleeding on probing, gingival index, plaque index were recorded. GCF and serum sMerTK and Gas6 levels were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by using non-parametric tests.

Eligibility

Inclusion Criteria:

  • Individuals without systemic diseases that may affect periodontal tissues (such as cardiovascular diseases, atherosclerosis, immune system disorders, rheumatoid arthritis, obesity, cancer, and diabetes)
  • Individuals who have not used antibiotics within the last 3 months
  • Individuals not taking any medications known to affect periodontal tissues
  • Individuals without infectious diseases such as HIV, hepatitis B virus (HBV), or tuberculosis
  • Individuals with at least 16 natural teeth, excluding third molars
  • Individuals aged 18 years and older

Exclusion Criteria:

  • Pregnant or lactating individuals
  • Individuals who have received periodontal treatment within the last 6 months
  • Current smokers

Study details
    Periodontitis

NCT07535177

Abant Izzet Baysal University

13 May 2026

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