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Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients

Comparison of Acoustic Variability Index (AVI) and Pulse Pressure Variation (PPV) for Predicting Fluid Responsiveness in Mechanically Ventilated Patients

Recruiting
19 years and older
All
Phase N/A

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Overview

The goal of this clinical trial is to learn if a new medical device called ResQ works to predict fluid needs in adults undergoing surgery under general anesthesia. The main questions it aims to answer are:

  • Can the Acoustic Variability Index (AVI) measured by ResQ predict if a participant needs more fluids as accurately as the standard arterial blood pressure-based method (PPV)?
  • Is the ResQ device safe to use during surgery? Researchers will compare the new method (AVI) to the standard method (PPV) to see if ResQ provides reliable information for managing patient fluids.

Participants will:

  • Undergo their planned surgery as scheduled.
  • Have a soft probe placed in the esophagus to monitor heart and lung sounds.
  • Receive a set amount of intravenous (IV) fluid as part of their regular surgery care.
  • Have their heart function checked before and after the fluids are given.

Eligibility

Inclusion Criteria:

  • Patients \> 18 years
  • Histological and cytological diagnosis of colorectal cancer neoplasia that has developed a liver metastasis
  • Patients who are candidates for surgery for colorectal cancer with liver metastasis
  • Signing of the relevant informed consent form.

Exclusion Criteria:

  • All exclusion criteria adopted in surgical protocols will be applied to the study

Study details
    Fluid Responsiveness Predictability
    Hemodynamic Monitoring
    Anesthesia
    General

NCT07516470

Signal House Co., Ltd.

13 May 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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