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A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus

Recruiting
18-65 years
All
Phase 2
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Overview

The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM

Eligibility

Inclusion Criteria:

  • Is an adult patient with a confirmed diagnosis of T2DM
  • Has a body mass index (BMI) of ≥25 kg/m\^2 and \<39.9 kg/m\^2
  • Has a hemoglobin A1c (HbA1c) ≥6.5% to \<10.5%
  • Is on a stable dose of metformin

Exclusion Criteria:

  • Has any clinically significant concomitant disease, medical condition, or abnormal laboratory finding that could compromise participant safety or confound interpretation of study results
  • Receiving therapies known to interfere with glucose or insulin metabolism other than current treatment for T2DM or birth control methods

Note: other protocol defined inclusion/exclusion criteria apply

Study details
    Type 2 Diabetes Mellitus (T2DM)

NCT07465224

Alnylam Pharmaceuticals

13 May 2026

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