Overview
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
Eligibility
Inclusion Criteria:
- A minimum of 10 healthy molars and premolars (DMFS of these teeth = 0)
- Willingness to use an electric (powered) toothbrush
- Willingness to use interdental floss
- Willingness to have bitewing radiographs taken
- Willingness to undergo an oral examination by an intraoral camera (DIAGNOcam)
Exclusion Criteria:
- Untreated caries \[clinical investigation and analysis with an intraoral camera (DIAGNOcam)\] (→ unsuitable subjects with one or two untreated caries in need of a restoration can become eligible after restorative therapy. If there are three or more untreated caries patients will be excluded)
- Xerostomia (medication, radiation, disease induced)
- Chemo/radiation therapy
- Physical or mental disability which prevents proper oral health care
- Orthodontic treatment
- Severe periodontitis at the Baseline Visit (pocket depth on at least one tooth ≥ 5.5 mm)
- Known hypersensitivity to one of the ingredients of the toothpastes to be tested
- Regular medication intake interfering with salivary function or flow
- Current pregnancy, the wish to become pregnant, the suspicion of being pregnant, or breastfeeding or in the course of the study
- 3 or more carious lesions/restorations in last 36 months until Baseline Visit
- Teeth missing due to caries in last 36 months until Baseline Visit
