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Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

Recruiting
55 years and older
All
Phase N/A

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Overview

The overall objective of the project is to determine the effectiveness of tele-delivered behavioral activation (BA) by trained lay counselors (Tele-BA-S) to prevent Post-stroke depression (PSD) in low-income, older stroke survivors with subthreshold depression (SD).

Eligibility

Inclusion Criteria:

  • Enrollment within 3-months +2 weeks of a first-time ischemic or hemorrhagic stroke
  • 24-item HDRS score \< 15 indicating subthreshold depression defined as the absence of depressive symptoms or presence of mild symptoms of depression
  • Single person income less than or equal to $45,000
  • Residing in a community residence
  • Ability to speak and read in English or Spanish
  • Mini-MoCA score \> or equal to 11

Exclusion Criteria:

  • Stroke event unrelated to vascular risk factors (e.g., drug use) or transient ischemic attack
  • 24-item HDRS score \> or equal to 15 indicating moderate to severe depression
  • Actively participating in psychotherapy
  • high suicide risk or severe psychiatric illness (e.g., bipolar disorder and active psychosis) and/or actively taking antipsychotics
  • Diagnosed dementia and/or currently taking cognitive enhancers, amyloid-targeting medications, or orexin receptor antagonists
  • Patient Health Questionnaire 9 score \> or equal to 10 and/or answers positive to Q9
  • Diagnosed aphasia and/or severe cognitive impairments
  • high-risk alcohol or drug misuse
  • receiving medications for mood disorders and a change in dose or type within the last 4 weeks

Study details
    Post-stroke Depression
    Subthreshold Depression

NCT06864715

The University of Texas Health Science Center, Houston

13 May 2026

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