Overview
Laryngeal dysplasia and progression to carcinoma: investigating genetic and immune alterations predictive of malignant transformation
Description
Evaluate the immune population of TILs in LDy lesions with a high or low risk of malignant transformation. Analyze gene expression profiles in LDy lesions categorized by their risk of malignant progression.
Eligibility
Inclusion Criteria:
- Histopathological diagnosis of laryngeal dysplasia.
- Age \>18 years and informed consent.
Exclusion Criteria:
- Prior surgical, radiotherapeutic, or oncologic treatments for head and neck regions.
- Congenital or acquired immunodeficiency disorders.
- Synchronous malignancies.
- Immunosuppressive therapy.
- Age \<18 years or absence of research consent.
