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Nicorandil as Anti-inflammatory in Rheumatoid Arthritis

Nicorandil as Anti-inflammatory in Rheumatoid Arthritis

Recruiting
18-70 years
All
Phase 3
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This study aims to evaluate the possible efficacy and safety of nicorandil as anti-inflammatory in managing patients with active rheumatoid arthritis.

Eligibility

Inclusion Criteria:

  • Patients with active rheumatoid arthritis (not in remission) according to American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) i.e., 28 joints disease activity score (DAS-28) \>2.6.
  • Patients receiving the conventional DMARDs

Exclusion Criteria:

  • Patients with heart disease (congestive heart failure, arrhythmia and ischemic heart disease), diabetes, active infection, and other illness except rheumatoid arthritis.
  • Patients with severe renal and hepatic dysfunction. - Patients receiving biological DMARDs.
  • Patients receiving oral prednisolone greater than 15mg/day.
  • Patients with hypersensitivity to study medications.
  • Patients using antioxidants.
  • Pregnant and lactating females.

Study details
    Rhumatoid Arthisis

NCT07516769

Tanta University

13 May 2026

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