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Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study

Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study

Recruiting
18 years and older
All
Phase N/A
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Overview

PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany. For the randomised part, 750 patients will be randomized to care within a heart failure network or usual care. The primary endpoint of the randomized trial is change in NT-proBNP from baseline to 6 months of follow-up.

All patients (randomized or not) will be followed for two years.

Description

See above.

Eligibility

Inclusion Criteria:

  • Patients admitted to the participating study centres with acute decompensated heart failure (ADHF), defined as clinical signs and/or symptoms of heart failure
  • objective structural cardiac abnormalitites according to the ESC criteria.

Exclusion Criteria:

  • Age \<18 years
  • pregnancy
  • any condition interfering with the informed consent process
  • patients placed in an institution by official or court order

Study details
    Heart Failure - NYHA II - IV

NCT06656832

University of Leipzig

13 May 2026

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