Overview
The goal of this observational study is to characterize the pupil light response in patients with delayed sleep-wake phase disorder. A subset of participants will take part in a clinical trial to determine if increasing serotonin can alter the circadian response to light. The main questions it aims to answer is:
Are there differences in the light response in patients with delayed sleep-wake phase disorder? Does citalopram increase melatonin suppression in patients with delayed sleep-wake phase disorder?
Participants will complete activity and melatonin testing at home to determine their circadian timing. This will be followed by an eye test looking at the pupil response to different light stimuli. A subset of participants will complete two inpatient admissions where melatonin levels will be sampled and they will be exposed to a bright light. During one round of testing they will receive a placebo and in the other round of testing they will take a single dose of citalopram, a selective serotonin reuptake inhibitor.
Eligibility
Inclusion Criteria:
- Diagnostic validated for one of the following pathologies:
- Ischemic stroke,
- Non-traumatic intracranial hematoma
- Cerebral venous thrombosis Diagnostic after December 31, 2007 Age \> 15 years on the date of the diagnostic Patient domiciled at the time of the diagnostic in one of the 79 communes defined beforehand
Exclusion Criteria:
- Age ≤ 15 years
- Validated diagnosis (see below, § 4.2.2) of aneurysmal subarachnoid hemorrhage cerebrovascular
- Diagnosis made before 1 January 2008
- Unconfirmed diagnosis
- Patient domiciled outside the previously defined area of residence
