Overview

This is an open-lable, multicenter Phase II study to evaluate the safety, tolerability, and efficacy of IBI363 in advanced melanoma patients

Eligibility

Inclusion Criteria:

• Male or Female, aged 18 years or above.
• Diagnosed with chronic stable heart failure NYHA Class 3 or 4 (either during most recent cardiology/heart failure clinic visit, or ADHF during recent/current hospitalization).
• Participant is willing and able to give informed consent for participation in the study.
• Participant has a smartphone device and can download a purposely designed mobile application on their phone (with guidance from the study investigators) or is willing to have sound recordings via a smartphone device loaned for the purpose of the study.

Exclusion Criteria:

• Unable to provide consent
• Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula
• Patients with currently known pneumonia
• Patients with known significant pulmonary disease including asthma, COPD, pulmonary fibrosis/interstitial lung disease, pulmonary hemorrhage.
• Patients with current Pulmonary embolus
• Patients with other intercurrent acute symptomatic illness (e.g., viral/bacterial infection) at time of recording
• Patients requiring continuous oxygen therapy at flow rates that cannot be provided through nasal cannula
• Patients with tracheostomy or who have undergone a surgical procedure to the head/neck/larynx which would affect the normal functioning of the vocal cords.
• Aphasic
• Patients excluded at PI discretion