Overview

The purpose of this study is to:

• evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of single ascending doses of ALN-2232 in patients with obesity
• evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 in patients with obesity
• evaluate the safety, tolerability, efficacy, PK, and PD of multiple doses of ALN-2232 co-initiated with tirzepatide in patients with obesity

Eligibility

Inclusion Criteria:

All Parts:

• Has a body mass index (BMI) of ≥30 kg/m\^2 and \<40 kg/m\^2
• Has a hemoglobin A1c (HbA1c) \<6.5%

Exclusion Criteria:

All Parts:

• Has any clinically significant concomitant disease, medical condition, or abnormal laboratory finding that could compromise participant safety or confound interpretation of study results
• Receiving therapies for chronic weight management or antidiabetic medications

Note: other protocol defined inclusion/exclusion criteria apply