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Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine

Topical Intranasal Anesthetic Block for Reducing the Pain of Botulinum Toxin Injections for Chronic Migraine

Recruiting
18 years and older
All
Phase N/A
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Overview

People find the injections used in onabotulinumtoxinA (Botox®) uncomfortable. This study will test whether putting a small piece of cotton soaked with 4% lidocaine (a numbing medicine) inside the front of each nostril for 5 minutes before the injections reduces injection pain compared with cotton soaked in saline (salt water).

Eligibility

Inclusion Criteria:

  • Aged ≥18 years
  • Any gender
  • Able to provide informed consent
  • Meets clinical criteria for onabotulinumtoxinA for chronic migraine (minimum of 2 days of disability per month due to facial or headache pain, or 8 headache days per month, or more than 15 headaches per month)
  • Scheduled for modified PREEMPT injections at the clinical site

Exclusion Criteria:

  • Aged \< 18 years
  • Trigeminal neuralgia, cluster headache, or other primary headache disorders as dominant diagnosis
  • Not able to provide informed consent
  • Known allergy/hypersensitivity to lidocaine or amide anesthetics
  • Pregnancy/lactation
  • Inability to tolerate intranasal nasal cotton pledgets
  • Significant nasal pathology at placement site

Study details
    Pain From onabotulinumtoxinA Injections

NCT07571889

Association of Migraine Disorders

13 May 2026

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