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CBCT Guided Markerless SBRT for Renal Cell Cancer

CBCT Guided Markerless SBRT for Renal Cell Cancer

Recruiting
18 years and older
All
Phase N/A

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Overview

This study aims to improve the treatment of kidney tumors using radiotherapy, by investigating whether kidney cancer can be more effectively irradiated with the help of new imaging techniques

Description

In total 40 patients will be treated for RCC using SBRT.

For 15 patients, additional breath-hold CBCT scans will be made during SBRT to investigate the intra- and inter-fraction uncertainty in breath-hold positions as well as assessing the feasibility of using surface guidance as a surrogate for target position.

Subsequently, 25 patients will be treated using the new motion management technique developed using the extra imaging data obtained from the first cohort of patients. It is hypothesized that either breath-hold or gating in combination with surface guidance will result in a reproducible (stable) position of the target and therefore minimal margins.

Eligibility

Inclusion Criteria:

  • Patients with histologically proven non-metastastic RCC or high suspicion of RCC based on imaging without histological evidence
  • No metastatic lesions
  • Patients must be 18 years or older
  • Ability to understand the requirements of the study and to give written informed consent, as determined by the treating physician.

Written informed consent

Exclusion Criteria:

  • Previous high-dose radiotherapy in the region of the kidney

Study details
    Renal Cell Carcinoma (RCC)

NCT07402109

Erasmus Medical Center

13 May 2026

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