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Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases

Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases

Recruiting
18-85 years
All
Phase 1/2

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Overview

The purpose of this study is to conduct clinical research on \[68Ga\] Ga-NI-FAPI-04 PET/CT imaging and further investigate its diagnostic value in fibroblast activation related diseases.

Description

Cardiorespiratory fitness is one of the 'health-related physical fitness' components of physical fitness and can be expressed as 'the ability of the heart, lung and vascular system to deliver oxygen and nutrients to working muscles'. Cardiopulmonary exercise testing (CPET) is a common procedure used to assess cardiopulmonary fitness, identify physiological factors limiting exercise, identify potential therapeutic targets for these factors, and evaluate the effects of an intervention. Therefore, in this project, it was aimed to investigate cardiorespiratory fitness and the factors affecting cardiorespiratory fitness in healthy adults. The data obtained with this project will be normative values for the data obtained with CPET in healthy people.

Eligibility

Inclusion Criteria:

  • 1: 18-85 years old 2: Tumor patients can undergo surgery or biopsy to obtain pathological diagnosis 3: Ability to understand and sign informed consent forms 4: Expected survival period exceeding 6 months and able to receive follow-up 5: Healthy volunteers without chronic medical history of hypertension, diabetes, coronary heart disease, kidney disease, tumor, etc

Exclusion Criteria:

  • 1: Pregnant or lactating women 2: Patients allergic to research drug ingredients 3: Patients with severe liver and kidney dysfunction (blood creatinine levels exceeding 159 μ mol/L) 4: Patients who participate in other clinical trials and interfere with the results of this study 5: Patients with severe illness who cannot cooperate with the examination

Study details
    Tumor
    Cardiovascular Diseases
    Pulmonary Fibrosis
    Rheumatic Immune Diseases Involving Large Blood Vessels
    Hypertrophic Cardiomyopathy (HCM)
    Other Hypoxic and Fibroblast Activated Diseases

NCT07464132

Peking Union Medical College Hospital

13 May 2026

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