Overview
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.
Eligibility
Inclusion Criteria Obese Participants:
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI ≥ 30 kg/m2
- No proven diagnose of diabetes
Inclusion Criteria Lean Participants:
- Age 18-60 years
- Written informed consent
- Scheduled for routine liquor puncture
- BMI 18-25 kg/m2
Exclusion Criteria:
- Known allergy to the natural odour
- Acute upper respiratory tract infection, acute or chronic sinusitis
- Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain
- Pregnancy/lactation
- Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate \<30 ml/min/m2)
- Inability to understand the study procedure and to sign the study consent
