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Progesterone-modified Natural Cycle for FET

Progesterone-modified Natural Cycle for FET

Recruiting
21-44 years
Female
Phase 3
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.

Eligibility

Inclusion Criteria:

  • Patients aged 21 to 44 years undergoing FBT
  • Body mass index (BMI) 18-35 kg/m2
  • Having regular ovulatory cycles

Exclusion Criteria:

  • Untreated uterine adhesions
  • Medical contraindications to estrogen and progesterone therapy
  • Illnesses contraindicating assisted reproductive technology or pregnancy
  • History of recurrent implantation failures (\> 2 embryo transfer failures)

Study details
    Infertility
    Female

NCT06644794

Shandong University of Traditional Chinese Medicine

13 May 2026

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