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Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.

Out-patiente Management for Gangrenous Acute Appendicitis: The PENDI-CSI II Randomized Clinical Trial.

Recruiting
14 years and older
All
Phase N/A

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Overview

PHASE II-III CLINICAL TRIAL TO EVALUATE THE SAFETY, EFFECTIVENESS AND EFFICIENCY OF DISCHARGE TO OUTPATIENT SURGERY IN PATIENTS WITH ACUTE GANGRENOUS APPENDICITIS UNDERGOING EMERGENCY SURGERY.

Eligibility

Inclusion Criteria:

  • Acute gangrenous appendicitis confirmed during surgery.
  • Patient who meets the criteria to be discharged on an outpatient basis
  • Signature of informed consent.
  • Older than 14 years of age

Exclusion Criteria:

  • \- Uncomplicated appendectomy.
  • Intra-operative purulent or faecaloid peritonitis
  • Appendicular abscess or plastron diagnosed by imaging.
  • Paralytic ileus preventing oral tolerance.
  • Need for placement of abdominal drainage.
  • ASA IV and some selected ASA III.
  • Immunosuppression.
  • Patients with active neoplasia.
  • Pregnancy.
  • Doubts in the definitive diagnosis.
  • Suspicion of inflammatory bowel disease.
  • No family support.
  • Failure to sign the informed consent form.
  • Impossibility to comply with the follow-up.

Study details
    Appendicitis Acute
    Gangrenous Appendicitis

NCT07521969

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

13 May 2026

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