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Antihistamine for Prevention of HTR After Blood Primed CPB

Antihistamine for Prevention of HTR After Blood Primed CPB

Recruiting
1-7 years
All
Phase 4
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Overview

This study will be a randomized, double-blinded, placebo-controlled study conducted at a university hospital. Forty children undergoing elective repair of a congenital heart defect will be included. The patients will be randomly allocated (20 patients per group) to receive a single intravenous dose of combined chlorpheniramine or normal saline immediately after separation from CPB, before protamine administration.

Eligibility

Inclusion Criteria:

  • Acyanotic congenital heart disease.
  • Age :1 -7 years.
  • Genre: both.

Exclusion Criteria:

  • Redo patient.
  • History of allergy to antihistamines.
  • Bleeding disorders with INR \> 1.5 and/or platelets \< 50,000.
  • Emergency procedure.

Study details
    Blood Transfusion Associated Adverse Reactions

NCT07536152

Kasr El Aini Hospital

13 May 2026

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