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Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

Early Myocardial Dysfunction Helps Identify Severe Refractory Pediatric Lupus

Recruiting
7-17 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.

Description

Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Although therapeutic advances have improved outcomes, a significant subset remains with severe disease activity despite optimal therapy, which is recognized as the severe refractory SLE (SR-SLE).A recent study using advanced echocardiographic techniques of global longitudinal strain (GLS) have revealed that left ventricular dysfunction is common in SLE patients and correlates with disease severity.The finding underscores the potential role of early myocardial dysfunction as a phenotypic marker of SR-SLE.To our knowledge, there are no validated biomarkers to reliably identify patients with SR-SLE at an early stage, especially in the pediatric population. Therefore, this study aimed to investigate biomarkers to identify pediatric SR-SLE patients.

Eligibility

Inclusion Criteria:

  • fulfill the American College of Rheumatology (ACR) criteria
  • disease onset at ages before 18 years

Exclusion Criteria:

  • patients with a history of concomitant malignancy
  • patients with active bacterial, viral, fungal, mycobacterial infection

Study details
    Systemic Lupus Erythematosus (SLE)

NCT07425730

Shanghai Jiao Tong University School of Medicine

15 May 2026

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