Overview
NEPTUNE Match is an additional opportunity offered to NEPTUNE study participants to prospectively recruit and communicate patient-specific clinical trial matching with kidney patients and their physician investigators.
Description
This is a prospective, open-label study testing the ability to effectively communicate patient-specific clinical trial matching with kidney patients and clinician investigators. The study consists of four components:
- Recruitment of participants from the NEPTUNE observational cohort study
- Generation of participant profile-trial match assessment using data from the NEPTUNE observational study and profiling units by the NEPTUNE Molecular Nephrology Board
- Establishing and testing a framework to communicate disease-trial drug mechanism matching with investigators and patients
- Retrospective comparison of kidney health outcomes in subjects enrolled in trials that aligned with their match vs. trial subjects with mis-aligned or unknown match alignment.
Eligibility
Inclusion Criteria:
- Consented and eligible participants in the biopsied or non-biopsied cohorts of the NEPTUNE observational study
- Must be potentially eligible for the NEPTUNE Match partnering trials (e.g. if no trial is enrolling a participant under age 6, those under 6 are not eligible).
Note: NEPTUNE Match partnering trials and associated eligibility criteria are expected to be dynamic and change as trial protocols are developed, activated, and amended.
- Regular nephrology healthcare provided at a NEPTUNE study site.
- Willing and able to consent, and as appropriate assent, to participate in NEPTUNE Match
Exclusion Criteria:
Currently non-NEPTUNE observational study participants are not eligible to be matched to a clinical trial using these biomarker assessments.
Exclusion Criteria:
1\. Non-English or non-Spanish speaking
