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Methadone in TKA for Post-op Pain and Opioid Reduction

Methadone in TKA for Post-op Pain and Opioid Reduction

Recruiting
18-75 years
All
Phase 3
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Overview

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

Eligibility

Inclusion

  • Ages 18-75 years of age
  • Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia

Exclusion

  • Allergy to methadone or mepivacaine
  • Severe liver disease defined as Child's Pugh Class C
  • End stage renal disease requiring dialysis
  • Known diagnosis of prolonged QT syndrome
  • Currently pregnant
  • Unable to provide written, informed consent
  • Non-English speaking

Study details
    Post Operative Pain

NCT07226076

Medical University of South Carolina

15 May 2026

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