Overview

A randomized controlled trial was conducted to compare the treatment efficacy of iRoot SP and nRoot SP Root Canal Sealer Materials in patients with chronic apical periodontitis.

Eligibility

Inclusion Criteria:

• Age ≥ 18 years.
• Diagnosis of apical periodontitis conforming to the diagnostic criteria in Endodontics.
• The affected tooth is deemed restorable upon evaluation, with non-vital pulp requiring extirpation.
• The affected tooth is a single tooth with a fully developed apical foramen.
• No root resorption and no significant morphological variation of the root canal.
• The affected tooth is undergoing primary root canal treatment.
• Periapical radiolucency with a diameter of 1-5 mm and no peripheral sclerotic border observed on preoperative radiographs.
• Patient is in normal mental state, conscious, and capable of normal communication.
• Patient has provided informed consent.

Exclusion Criteria:

• Patients with alveolar bone loss exceeding one-third of the root length.
• Affected teeth with root fracture, root canal obstruction, calcification, or root surface caries.
• Patients with severe systemic diseases (e.g., osteoporosis, mental disorders, hepatic or renal insufficiency).
• Patients who have taken analgesics, immunosuppressants, or antibiotics within one week prior to enrollment.
• Patients with concurrent periapical cysts, oral tumors, or other oral diseases.
• Pregnant or lactating patients.
• Patients with dental phobia, severe gag reflex, limited mouth opening, or poor compliance.
• Patients with a known allergy to the root canal sealer materials.