Overview
The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:
- Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol?
- Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging?
- How does embryo quality (KIDScore) compare between the two protocols?
Study Design:
Researchers will randomly assign 148 women undergoing IVF to two groups:
- PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle
- GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm
Participants will:
- Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days
- Have regular ultrasound monitoring and blood tests to track follicle development
- Undergo egg retrieval procedure when follicles are mature
- Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring
- Have embryos frozen on Day 5/6 for future transfer
Study Location:
Department of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital
Study Duration: January 2026 - June 2028
Eligibility
Inclusion Criteria:
- Women aged 20-45 years
- Indicated for in vitro fertilization (IVF) treatment
- Planned freeze-all embryo strategy
- Voluntary participation in research.
Exclusion Criteria:
- Systemic diseases
- Use of hormonal medications within 3 months prior to enrollment
- Oocyte donation cycles
- Unwilling or unable to participate in research