Overview
This study aims to compare the effectiveness of secretome injection and intradermal platelet-rich plasma (PRP) injection on hair density and the terminal-to-vellus hair ratio in patients with androgenetic alopecia at Prof. Dr. I.G.N.G. Ngoerah General Hospital.
Description
This research is an experimental study with a randomized controlled clinical design involving two intervention groups: one receiving secretome injections and the other receiving intradermal platelet-rich plasma injections. Evaluations are conducted by measuring hair density and the terminal-to-vellus hair ratio before and after treatment using trichoscopy/dermoscopy.
Eligibility
Inclusion Criteria:
- Male patients with androgenetic alopecia, aged 25 to 59 years, with clinical presentation consistent with Hamilton-Norwood grades II to VI, seeking treatment at the Dermatology and Venereology Outpatient Clinic of Prof. Dr. I.G.N.G. Ngoerah General Hospital.
- Female patients with androgenetic alopecia, aged 25 to 59 years, with clinical presentation consistent with Ludwig grades I to III, seeking treatment at the Dermatology and Venereology Outpatient Clinic of Prof. Dr. I.G.N.G. Ngoerah General Hospital.
- Female patients who are not currently pregnant or breastfeeding.
- Patients who have discontinued anti-androgen medication and minoxidil for at least 1 month prior to the procedure.
- Patients with no known allergies to secretome components and/or materials used in the platelet-rich plasma (PRP) preparation process.
- Patients who are proficient in Indonesian and willing to provide written informed consent.
Exclusion Criteria:
- Participants who are unable to speak or understand Indonesian and/or are unwilling to provide written informed consent.
- Patients presenting with types of hair loss other than androgenetic alopecia.
- Patients currently undergoing therapy with 5-alpha reductase inhibitors.
- Patients who have received intradermal corticosteroid injections to the scalp within at least 6 months prior to the study.
- Patients with active infections and/or active dermatitis on the scalp.
- Patients with a known history of allergy to secretome components and/or materials used in the platelet-rich plasma (PRP) preparation process.
- History of hypertrophic scarring or blood clotting (coagulation) disorders.
- Patients unable to complete the research procedures in their entirety.
