Overview
Recently, several salivary biomarkers (proteins and nucleic acids) of sport related concussion have been identified in professional athletes. However, their reference values have not been determined with sufficient robustness to enable their employment in concussion diagnostic tests. Toward a proper interpretation of the signal for a reliable diagnostic test, we aim to evaluate the physiological variations as well as the effect of different intensive trainings on the profile of these salivary biomarkers in professional athletes. Data generated form such analysis will help establish a baseline profile for these biomarkers whose change in intensity associated with concussion could be diagnosed in the future.
Eligibility
Inclusion Criteria:
- Male participants aged between 18 and 50 years old.
- Participants willing to comply with the study procedures.
- Participants capable of understanding the purpose, nature, and methodology of the study.
- Participants affiliated to a French social security system or beneficiaries of such a system.
- Participants who have signed the non-opposition form to participate in the research.
Non-inclusion Criteria:
- Participant not affiliated to a French social security system or not a beneficiary of such a system.
- Participants deprived of liberty, protected adults, vulnerable individuals, or minors.
- Participants with a proven or suspected chronic infectious disease that may introduce a risk of contamination during sample handling (laboratories not equipped to handle this type of sample).
- Refusal to sign the non-opposition form to participate in the research.
Non-inclusion specific criteria
- Subject who has had a recent stroke or epilepsy event (within the past two months).
- Subject suffering from neurological diseases.