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Neurophysiology of Reward Signaling in Parkinson's Disease

Neurophysiology of Reward Signaling in Parkinson's Disease

Recruiting
40 years and older
All
Phase N/A
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Overview

The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Eligibility

Inclusion Criteria:

  • Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
  • Planned clinical electrode trajectory that contacts caudate
  • Age greater than or equal to 40
  • Diagnosis of Parkinson's disease or other movement disorder
  • Able to participate in intraoperative testing
  • English speaking

Exclusion Criteria:

  • Age less than 40
  • Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)

Study details
    Parkinson Disease

NCT07409207

Vanderbilt University Medical Center

26 February 2026

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