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The PRE-VAIL Study

The PRE-VAIL Study

Recruiting
18 years and older
All
Phase N/A

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Overview

During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe mechanically ventilated acute respiratory distress syndrome (ARDS).

The experimental group had the enteral nutrition dose reduced before the prone position, while the control group did not have the enteral nutrition dose reduced

Description

During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe mechanically ventilated ARDS.

The experimental group had the enteral nutrition dose reduced before the prone position, while the control group did not have the enteral nutrition dose reduced

Eligibility

Inclusion Criteria:

  • Age ≥18 years old
  • Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)
  • Meet the diagnostic criteria for moderate/severe ARDS (even after optimizing the ventilation Settings, the oxygenation index is still \< 150mmHg and PEEP is still ≥5 cm H2O)
  • It is expected to stay in the ICU for more than 48 hours

Exclusion Criteria:

  • There are contraindications for the prone position
  • There are contraindications for EN, preventing the initiation of early EN (≤48 hours)
  • Expected to die within 48 hours
  • Pregnancy

Study details
    ARDS (Moderate or Severe)
    Prone Position
    Enteral Nutrition Feeding
    Intensive Care Unit (ICU) Admission

NCT07176624

The First Hospital of Jilin University

26 February 2026

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