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Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments

Optimization of Perioperative Antibiotic Prophylaxis in Patients Allergic to Beta-lactams in the Orthopedic Surgery and Trauma Departments

Recruiting
18 years and older
All
Phase N/A

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Overview

To evaluate the real-world effectiveness and implementation strategies for mPATH-Lung, investigators propose a pragmatic, randomized controlled trial across an academic Learning Health System. The trial will contrast several approaches to participant outreach and will specifically target engaging fully powered cohorts of racial/ethnic minorities and rural residents.

Description

Primary Objective: Evaluate the real-world effectiveness of mPATH-Lung in increasing lung cancer screening rates across diverse populations.

Secondary Objectives

  • Compare the differential effectiveness of three outreach strategies for engaging participants with mPATH-Lung across vulnerable rural or ethnic/racial minority population subgroups.
  • Estimate the additional revenue generated by mPATH-Lung through increased screening and downstream care.
  • Evaluate the potential for over-screening and the impact of applying HEDIS-based exclusion criteria

Eligibility

Inclusion Criteria:

  • Adult patient (≥ 18 years old)
  • Patient operated on at Strasbourg University Hospital between January 1, 2023, and December 31, 2023, for total knee, shoulder, or hip replacement.
  • Patients who underwent surgery at Strasbourg University Hospital between March 1, 2025, and July 31, 2025, involving surgery requiring intraoperative antibiotic prophylaxis.

Exclusion Criteria:

  • Patients with a surgical indication without the use of implants.
  • Patients with a surgical indication without antibiotic prophylaxis.

Study details
    Beta Lactam Adverse Reaction

NCT07342647

University Hospital, Strasbourg, France

13 May 2026

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