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School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions

School-based Program for the Prevention of Rheumatic Heart Disease in Endemic Regions

Recruiting
5-16 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.

We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.

The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.

Eligibility

Inclusion Criteria:

\- Children aged 5-16 years

Exclusion Criteria:

  • Children / primary caregivers not providing informed consent to participate
  • Children not attending one of the selected schools

Study details
    Rheumatic Heart Disease in Children

NCT06720272

Thomas Pilgrim

1 February 2026

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