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Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis

Immune Profile and Respiratory Parameters in Down Syndrome Children With Acute Pneumonia: Pre-Intervention Analysis

Recruiting
1-6 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age

Description

descriptive, cross-sectional study analyzed baseline data from 40 children with DS and acute pneumonia enrolled prior to intervention in a larger trial. Baseline serum IgG, IgA, IgM (nephelometry), total WBC count (automated analyzer), RR (manual count), and SaO2 (pulse oximetry) were measured. Pearson or Spearman correlations were used to assess relationships between immune and respiratory variables, and with age.

Eligibility

Inclusion Criteria:

  • Down Syndrome with acute bronchopneumonia
  • sufficient cognitive ability

Exclusion Criteria:

  • severe congenital heart defects
  • primary immunodeficiencies

Study details
    Down Syndrome

NCT07366593

Badr University

1 February 2026

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