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The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

The Physiological Effect of RCexp on Ventilation/Perfusion Distribution

Recruiting
19 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Description

With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.

Eligibility

Inclusion Criteria:

adult patients with ARDS receiving mechanical ventilation no more than 72 hours

Exclusion Criteria:

  1. age \<18 years old
  2. patient undergoing legal protection
  3. contra-indications to EIT (e. g. severe chest trauma or wounds)
  4. pneumothorax
  5. patient undergoing ECMO
  6. pregnancy

Study details
    Acute Respiratory Distress Syndrome
    Mechanical Ventilation

NCT06919484

Southeast University, China

31 January 2026

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