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Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications

Roles of Hepatic Insufficiency, Hepatic Fibrosis, and Inorganic Pyrophosphate in the Progression of Arterial Calcifications

Recruiting
18 years and older
All
Phase N/A
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Overview

Individuals with metabolic syndrome (MetS), particularly those with type 2 diabetes (T2D), and/or metabolic dysfunction-associated steatohepatitis or MASH face an elevated risk of major cardiovascular events (MACE). We showed decrease plams level of PPi in patients with liver cirrhosis. We hypothezised that liver transplant should block AC and restore PPi plasma level.

Eligibility

Inclusion Criteria:

  • everyone requiring liver transplantation for the treatment of a chronic liver disease

Exclusion Criteria:

  • MELD score \>25, viral replication

Study details
    Liver Cirrhosis

NCT07201649

Centre Hospitalier Universitaire de Nice

31 January 2026

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