Overview
The objective of this randomized cross-over trial is to assess the physiological effects of three different facemasks for noninvasive ventilation (Nivairo, Visairo, Optiniv) in patients with acute hypercapnic respiratory failure
Eligibility
Inclusion Criteria:
Acute respiratory failure with
- PaCO2 ≥ 45 mmHg;
- Arterial pH \< 7.35;
- Signed written informed consent
Exclusion Criteria:
- Respiratory rate \< 12 bpm;
- Immediate need for intubation;
- Haemodynamic instability (Systolic blood pressure \<90 mmHg or mean arterial pressure \<65 mmHg) and/or lactic acidosis (lactate \>5 mmol/L) and/or clinically diagnosed shock;
- Metabolic Acidosis;
- Recent head surgery or anatomy that prevent the application of facemasks;
- Any contraindications to oesophageal balloon insertion and/or electrical impedance tomography (EIT) belt placement.
- Any contraindications to facemask noninvasive ventilation.
