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Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)

Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)

Recruiting
18 years and older
All
Phase N/A
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Overview

The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with unresectable mCRC.

Eligibility

Inclusion criteria:

\- Adults (≥18 years of age) schduled to undergo chemotherapy for the treatment of unresectable metastatic colorectal cancer.

Exclusion criteria :

  • Pregnancy.
  • A life expectancy of \< 6 months.
  • Absolute contraindications to maximal exercise, as per the recommendations by the Danish Society of Cardiology.
  • ECOG (Eastern Cooperative Oncology Group) performance status \> 2.
  • Inability to understand the Danish or English language.
  • Engagement in structured moderate-to-high aerobic exercise training for \>30 min \>1 times/week for the past 3 months at the time of inclusion.

Study details
    Metastatic Colorectal Cancer (mCRC)

NCT06938971

Rigshospitalet, Denmark

14 May 2026

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