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Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

Phase 1b Study of VERVE-201 in Patients With Refractory Hyperlipidemia

Recruiting
18-70 years
All
Phase 1
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Overview

VT-20101 is an Open-label, Phase 1b, Single-ascending dose study that will evaluate the safety of VERVE-201 administered to patients with Refractory Hyperlipidemia.

VERVE-201 uses base-editing technology designed to inactivate the expression of the ANGPTL3 gene in the liver and lower circulating low-density lipoprotein cholesterol (LDL-C) and triglycerides. This study is designed to determine the safety and pharmacodynamic profile of VERVE-201 in this patient population.

Eligibility

Inclusion Criteria:

  • Refractory hypercholesterolemia
  • Refractory hypertriglyceridemia

Exclusion Criteria:

  • Active or history of chronic liver disease
  • Current treatment with monoclonal antibody targeting ANGPTL3 or prior treatment within specified timeframe
  • Clinically significant or abnormal laboratory values as defined by the protocol

Study details
    Hypercholesterolemia
    Hypertriglyceridemia
    Refractory Hyperlipidemia

NCT06451770

Verve Therapeutics, Inc.

13 May 2026

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