Overview
The primary objective of this study is to assess the safety and tolerability of KN060 in patients with end-stage renal disease on regular hemodialysis.
The secondary objectives to evaluate the pharmacokinetic and pharmacodynamic properties of multiple doses of KN060; to evaluate the immunogenicity of KN060; and to explore the efficacy of KN060 in preventing dialyzer and extracorporeal circuit thrombosis, arteriovenous fistula thrombosis in patients with end-stage renal disease undergoing regular hemodialysis. The main questions it aims to answer are:
- Whether KN060 is safe for ESRD dialysis patients
- Pharmacokinetic characteristics of KN060 in ESRD dialysis patients
- Whether KN060 can effectively prevent dialyzer and extracorporeal circuit thrombosis Researchers will evaluate the safety, tolerability, Pharmacokinetics and Pharmacodynamics profile, dialyzer and extracorporeal circuit thrombosis, arteriovenous fistula thrombosis of KN060 in ESRD dialysis patients
Subjects will :
- Eligible subjects will receive KN060 2.5 mg/kg every two weeks for a total of 6 doses.
- Assessed for the number, incidence, and severity of AEs, dialyzer thrombus, extracorporeal circuit thrombus, arteriovenous fistula thrombus, and time to hemostasis at the arteriovenous fistula puncture site.
Eligibility
Inclusion Criteria:
1. Male or female subjects aged between 18 and 80 years (inclusive);
2. 1 8 kg /m \^2 \100 mg/day (investigators are allowed to use heparin / low molecular weight heparin during dialysis, depending on the situation );
5. There is a high risk of bleeding, or abnormal bleeding-related indicators:
1） Bleeding requiring hospitalization or clinically significant active bleeding within 3 months before screening ; prolonged arteriovenous fistula compression time within the past month; 2） Platelet count (PLT) \<100 × 10\^ 9 /L ( PLT between 75-100 × 10\^9 /L , determined by the investigator after comprehensive evaluation), hemoglobin ( Hb ) \< 90 g/L ; 3） Normalized ratio INR\>1.4 , activated partial thromboplastin time ( APTT ) \> 1.2 times ULN ; 4） Liver disease-related laboratory abnormalities: increased bleeding risk due to coagulation disorders , alanine aminotransferase (ALT) \> 3 times ULN , aspartate aminotransferase ( AST) \> 3 times ULN , total bilirubin (TB) \> 2 times ULN and direct bilirubin proportion \> 20%; 5） Poor blood pressure control in the past month before screening (judged by the investigator, such as repeated diastolic blood pressure ≥100 mmHg and/or systolic blood pressure ≥180 mmHg ) ; 6） Underwent brain, spinal or eye surgery (excluding cataract surgery) within three months before screening; 7） The patient has a bleeding disorder, a medical history that may increase the risk of bleeding, any condition that the investigator believes increases the risk of bleeding, or a history of severe bleeding disorders, such as massive gastrointestinal bleeding or cerebral hemorrhage ; 6. Supine blood pressure is \< 90/50 mmHg , or \> 170/100 mmHg (one retest is allowed) during screening; 7. Electrocardiogram during screening: heart rate \< 45 beats / min or \> 110 beats / min, QTcF \> 500 ms, any significant arrhythmia or conduction abnormality ( e.g. Second degree or above atrioventricular block, preexcitation syndrome (except those who have undergone radical radiofrequency ablation) , non-sustained or sustained ventricular tachycardia (one retest is allowed); 8. History (\<1 year) of drug or alcohol abuse or dependence before screening; 9. Have a history of allergy, or be allergic to the experimental drug/similar drugs or excipients; 10. Human immunodeficiency virus (HIV ) infection, syphilis infection, active HBV infection (HBV -DNA\>ULN ), active HCV infection (HCV - RNA \> ULN ) ; 11. Participated in another clinical trial and received trial drugs within 3 months before screening (signing ICF); 12. Plan to receive a kidney transplant during the trial or within 3 months after completing this trial; 13. Xanthine, coffee (small amounts of caffeine from normal food sources, such as chocolate, are permitted), or alcohol cannot be prohibited during the study; 14. Any concomitant disease or condition that the investigator believes may interfere with the study drug, affect study data, or pose a risk to patient safety.
