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Deep Learning for Automated Discrimination Between Stage T1-T2 and T3 Renal Cell Carcinoma on Contrast-Enhanced CT

Deep Learning for Automated Discrimination Between Stage T1-T2 and T3 Renal Cell Carcinoma on Contrast-Enhanced CT

Recruiting
18-85 years
All
Phase N/A

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Overview

This study aims to develop and validate a contrast-enhanced CT-based deep-learning model for automatic and accurate preoperative discrimination between T1-T2 and T3 renal cell carcinoma. By quantifying the model's diagnostic performance on an independent test set-using AUC, sensitivity, specificity, positive/negative predictive values, and decision-curve analysis-we will establish a decision-support tool that can be seamlessly integrated into clinical PACS, thereby reducing staging errors, refining surgical planning, and improving patient outcomes.

Eligibility

Inclusion Criteria:

  1. Histopathologically confirmed renal cell carcinoma on postoperative specimen.
  2. Preoperative contrast-enhanced CT performed at our institution with slice thickness ≤ 1 mm and complete DICOM datasets.
  3. Postoperative pathologic staging clearly defined as pT1a-T2b or pT3a.
  4. CT image quality deemed adequate for analysis.

Exclusion Criteria:

  • 1\. Pathologic subtype other than RCC. 2. Images with severe artifacts.

Study details
    Carcinoma
    Renal Cell
    Diagnostic Imaging
    Pathology
    Deep Learning

NCT07166445

Peking University First Hospital

13 May 2026

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