Image

Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.

Clonal Hematopoiesis of Indeterminate Potential in Heart Failure.

Recruiting
18 years and older
All
Phase N/A

Powered by AI

Overview

Study will be directed to evaluate the dentoalveolar changes following maxillary incisor intrusion using utility arch assisted with micro-osteoperforations in deep bite cases.

Description

Micro-osteoperforations (MOPs) are a new, simple, and minimally invasive technique to accelerate tooth movement. The biologic mechanism behind MOPs is to increase the cytokine expression that leads to increased bone resorption, the catabolic phase of tooth movement, in the direction of tooth movement. Transmucosal holes in cortical bone are made to trigger bone remodeling changes for faster tooth movement and decrease root resotption.

Eligibility

Inclusion Criteria:

  1. Patients age between 15-25 years.
  2. Patients with overbite ≥ 4 mm.
  3. All permanent teeth erupted (excluding 3rd molars).
  4. No previous orthodontic treatment.
  5. Patients with good oral hygiene and good periodontal health.

Exclusion Criteria:

  1. Skeletal discrepancies.
  2. Missing maxillary anterior teeth or any kind of tooth/root shape anomaly.
  3. Patients with root resorption or impacted canines.
  4. Previous history of orthodontic treatment.
  5. Systemic disease interferes with orthodontic tooth movement.
  6. History of trauma affecting the maxillary incisors.
  7. Poor oral hygiene or periodontally compromised patient.
  8. Endodontically treated upper anterior teeth.

Study details
    Heart Failure

NCT06626685

FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS

13 May 2026

Step 1 Get in touch with the nearest study center
We have submitted the contact information you provided to the research team at {{SITE_NAME}}. A copy of the message has been sent to your email for your records.
Would you like to be notified about other trials? Sign up for Patient Notification Services.
Sign up

Send a message

Enter your contact details to connect with study team

Investigator Avatar

Primary Contact

  Other languages supported:

First name*
Last name*
Email*
Phone number*
Other language

FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
Add a private note
  • abc Select a piece of text.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.