Overview
A prospective ,multicenter ,non-interventional ,real-world study observing changes in molecular markers after three weeks of osimertinib targeted therapy in EGFRm NSCLC
Description
A prospective ,multicenter ,non-interventional ,real-world study observing changes in molecular markers after three weeks of osimertinib targeted therapy in Chinese patients with stage IIIB ,IIIC ,or IV metastatic or recurrent non squamous EGFR-positive non-small cell lung cancer
Eligibility
Inclusion Criteria:
- Male or female,age ≥18 years.
- Newly diagnosed,histologically confirmed,and classified as stage IIIB,IIIC,IV or recurrent NSCLC which are not amenable to curative surgery or radiotherapy .
- No prior systemic antitumor therapy, including EGFR -TKIs or immunotherapy .
- Presence of an EGFR mutation confirmed by a local laboratory in blood or tissue samples .
- Adequate blood samples available for molecular testing .
- Provision of written informed consent .
Exclusion Criteria:
- Inability to provide plasma samples at baseline .
- Baseline blood EGFR mutation status not confirmed by the central laboratory .
- Refusal to receive subsequent treatment with osimertinib .
- Any condition that ,in the investigator's judgment ,could interfere with study procedures or confound outcome assessment .
