Overview
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
Eligibility
Inclusion Criteria:
- scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)
- under cardiopulmonary bypass
- Affiliation to the French national healthcare system
- Written consent obtained
Exclusion Criteria:
- age<18
- weight<50 kg
- chronic use of NSAID
- mini-invasive surgery
- NSAID contraindication
- NSAID allergy
- Nefopam contraindication
- Paracetamol contraindication
- Tramadol contraindication
- Urgent surgery
- Endocarditis
- Immunosuppressive drug
- HIV infection with CD4<200 mm3
- Organ transplantation
- Stage 4 or 5 chronic kidney disease
- Gastro duodenal ulcer
- Pregnancy
- Depression
- Auto immune disease