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Non-steroidal Anti-inflammatory in Cardiac Surgery

Recruiting
18 years of age
Both
Phase N/A

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Overview

Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.

Eligibility

Inclusion Criteria:

  • scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)
  • under cardiopulmonary bypass
  • Affiliation to the French national healthcare system
  • Written consent obtained

Exclusion Criteria:

  • age<18
  • weight<50 kg
  • chronic use of NSAID
  • mini-invasive surgery
  • NSAID contraindication
  • NSAID allergy
  • Nefopam contraindication
  • Paracetamol contraindication
  • Tramadol contraindication
  • Urgent surgery
  • Endocarditis
  • Immunosuppressive drug
  • HIV infection with CD4<200 mm3
  • Organ transplantation
  • Stage 4 or 5 chronic kidney disease
  • Gastro duodenal ulcer
  • Pregnancy
  • Depression
  • Auto immune disease

Study details

Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery, Pain Intensity, Multimodal Pain Management

NCT06381063

Centre Hospitalier Universitaire, Amiens

4 May 2024

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